SrasV1, Main, Exploration, bibRecord, 002395

Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome.

Identifieur interne : 002395 ( Main/Exploration ); précédent : 002394; suivant : 002396

Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome.

Auteurs : Jean-Paul Armache [Allemagne] ; Alexander Jarasch [Allemagne] ; Andreas M. Anger [Allemagne] ; Elizabeth Villa [Allemagne] ; Thomas Becker [Allemagne] ; Shashi Bhushan [Allemagne] ; Fabrice Jossinet [France] ; Michael Habeck [Allemagne] ; Gülcin Dindar [Allemagne] ; Sibylle Franckenberg [Allemagne] ; Viter Marquez [Allemagne] ; Thorsten Mielke [Allemagne] ; Michael Thomm [Allemagne] ; Otto Berninghausen [Allemagne] ; Birgitta Beatrix [Allemagne] ; Johannes Söding [Allemagne] ; Eric Westhof [France] ; Daniel N. Wilson [Allemagne] ; Roland Beckmann [Allemagne]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2010-10-25.

RBID : Hal:hal-00530578

Abstract

Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectron microscopy reconstructions of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution, together with a 6.1-Å map of a translating Saccharomyces cerevisiae 80S ribosome, we have localized and modeled 74/80 (92.5%) of the ribosomal proteins, encompassing 12 archaeal/eukaryote-specific small subunit proteins as well as the complete complement of the ribosomal proteins of the eukaryotic large subunit. Near-complete atomic models of the 80S ribosome provide insights into the structure, function, and evolution of the eukaryotic translational apparatus.

Url:

https://hal.archives-ouvertes.fr/hal-00530578

DOI: 10.1073/pnas.1010005107

Affiliations:

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Le document en format XML

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<author><name sortKey="Wilson, Daniel N" sort="Wilson, Daniel N" uniqKey="Wilson D" first="Daniel N" last="Wilson">Daniel N. Wilson</name>
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          <desc>            <address>              <addrLine>Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen- Strasse 25, 81377 Munich</addrLine>
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<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Beckmann, Roland" sort="Beckmann, Roland" uniqKey="Beckmann R" first="Roland" last="Beckmann">Roland Beckmann</name>
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          <desc>            <address>              <addrLine>Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen- Strasse 25, 81377 Munich</addrLine>
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<idno type="DOI">10.1073/pnas.1010005107</idno>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America </title>
<idno type="ISSN">0027-8424</idno>
<imprint><date type="datePub">2010-10-25</date>
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<front><div type="abstract" xml:lang="en">              <p>Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectron microscopy reconstructions of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution, together with a 6.1-Å map of a translating Saccharomyces cerevisiae 80S ribosome, we have localized and modeled 74/80 (92.5%) of the ribosomal proteins, encompassing 12 archaeal/eukaryote-specific small subunit proteins as well as the complete complement of the ribosomal proteins of the eukaryotic large subunit. Near-complete atomic models of the 80S ribosome provide insights into the structure, function, and evolution of the eukaryotic translational apparatus.</p>
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</front>
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<tree><country name="Allemagne"><noRegion><name sortKey="Armache, Jean Paul" sort="Armache, Jean Paul" uniqKey="Armache J" first="Jean-Paul" last="Armache">Jean-Paul Armache</name>
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<name sortKey="Dindar, Gulcin" sort="Dindar, Gulcin" uniqKey="Dindar G" first="Gülcin" last="Dindar">Gülcin Dindar</name>
<name sortKey="Franckenberg, Sibylle" sort="Franckenberg, Sibylle" uniqKey="Franckenberg S" first="Sibylle" last="Franckenberg">Sibylle Franckenberg</name>
<name sortKey="Habeck, Michael" sort="Habeck, Michael" uniqKey="Habeck M" first="Michael" last="Habeck">Michael Habeck</name>
<name sortKey="Jarasch, Alexander" sort="Jarasch, Alexander" uniqKey="Jarasch A" first="Alexander" last="Jarasch">Alexander Jarasch</name>
<name sortKey="Marquez, Viter" sort="Marquez, Viter" uniqKey="Marquez V" first="Viter" last="Marquez">Viter Marquez</name>
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<name sortKey="Wilson, Daniel N" sort="Wilson, Daniel N" uniqKey="Wilson D" first="Daniel N" last="Wilson">Daniel N. Wilson</name>
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<name sortKey="Westhof, Eric" sort="Westhof, Eric" uniqKey="Westhof E" first="Eric" last="Westhof">Eric Westhof</name>
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Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome.

Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome.

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